Connecting Genomics ↔️ Proteins and Mechanism using
Protein Structural Bioinformatics | Machine Learning | Computational Biophysics
Welcome to the Iqbal Lab Website!
The Iqbal Lab—a Bioinformatics and Machine Learning Group—is part of the Ladders 2 Cures (L2C) Accelerator Initiative at the Broad Institute of MIT and Harvard in Cambridge, MA, USA. It is led by Sumaiya Iqbal. We develop methods, resources, and tools to decipher the protein structure-function relationship between genetic/synthetic mutations and molecular phenotypes to aid in translating genetic discovery into mechanism and drug discovery.
The focus of Iqbal Lab is threefold:
➡️ Build bioinformatics resources to bridge the gap across complex multi-omics data types (genomics, transcriptomics, proteomics, and structural biology) at scale to aid in the wholistic analysis of drug target ↔ disease pairs.
➡️ Generate methods to unveil the molecular effect of genetic/synthetic mutations on protein structure-function relationships using computational biology, biophysics, and machine learning.
➡️ Develop AI/ML-driven innovative tools and technology for small-molecule hit identification using data from DNA-encoded library screening, HTS, etc.
We work across all disease areas, with a special focus on rare genetic diseases and pediatric cancer.
Our lab is known for developing and maintaining the Genomics 2 Proteins Portal ↗️ check it out!
Learn more about our Projects, Resources, & Publications!
"A life doesn't become miserable for having too much to do but for having nothing to do"
- Fyodor Dostoevsky
Sep, 2024
Published today @SpringerNature in @naturemethods, Genomics 2 Proteins portal @G2Pportal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures.
https://www.nature.com/articles/s41592-024-02409-0 ↗️
Aug, 2024
Sumaiya gives Genomics 2 Proteins portal workshop at the Cancer Genomics Consortium (CGC) annual meeting, Bioinformatics workshop session. Read more ➡️
May, 2024
Great time and lab participation at the Mutational Scanning Symposium (MSS'24). Jordan gave a talk on the G2P portal, Francesca presented a poster on our ION channel variant effect project, and Sumaiya shared feedback on the post-symposium newsletter! Read more ➡️
Feb, 2024
Another fantastic Biophysical Society Annual Meeting (BPS'24) in Philadelphia! Computational biophysics and Structural bioinformatics are the two primary toolboxes we use to investigate the effect of genetic mutations on protein structure-function relationship. Congratulations to Seulki for giving a platform talk and Jordan for presenting a poster. Read more ➡️
More news ➡️
